IPK Superfamily (肌醇多磷酸激酶 (IPK) 超家族)

Inositiol Polyphosphate Kinase (IPK) Superfamily is a family of enzymes that have a similar 3-dimensional structure. All members of the family catalyze the transfer of phosphate groups from ATP to various inositol phosphates. Members of the family include inositol-polyphosphate multikinases (IPMK), inositol-hexakisphosphate kinases, inositol-trisphosphate 3-kinases (PI3K) and inositol-pentakisphosphate 2-kinase (IP5P2K). Members of the IPK superfamily play important roles in various signaling pathways by altering the phosphorylation state of the second messenger inositol phosphates. Some members of the IPK superfamily are involved in regulating inositol phosphate metabolism related to vesicle transport, ensuring the accurate progress of intracellular substance transport. Abnormal functions of IPK superfamily members are closely related to the occurrence and development of various diseases, such as cancer, neurological diseases, and metabolic diseases^[1][2][3].